GenderBiology.net

Genomic Health Study Shows Breast Cancers In Men Display Very Similar Gene Signatures To Those In Women

SOURCE:  Medical News Today

DATE:  May 30, 2009

EXCERPT: " ....  breast cancer in men displays similar gene signatures to female breast cancer."    more

RELATED LINKS:

Poster presentation on Monday, June 1 (1:00 - 5:00 p.m. ET)
S. Shak, G. Palmer, F. L. Baehner, C. Millward, D. Watson, G. W. Sledge; Genomic Health, Redwood City, CA; Indiana University School of Medicine, Indianapolis, IN. Molecular characterization of male breast cancer by standardized quantitative RT-PCR analysis: First large genomic study of 347 male breast cancers compared to 82,434 female breast cancers.Poster presentation.   American Society of Clinical Oncology (ASCO) Annual Meeting, 2009 May 29- June 2,  Orlando, FL. Abstract 549.

See also J Clin Oncol 27:15s, 2009 (suppl; abstr 549)

UCLA Discovery May Explain Why Autism Strikes Boys Four Times More Than Girls

SOURCE:  Medical News Today

DATE:  May 20, 2009

EXCERPT: "UCLA scientists have discovered a variant of a gene called CACNA1G that may increase a child's risk of developing autism, particularly in boys."   more

RELATED PUBMED LINK:

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Strom SP, Stone JL, Ten Bosch JR, Merriman B, Cantor RM, Geschwind DH, Nelson SF. The journal Molecular Psychiatry publishes the findings in its May 19 advance online edition. High-density SNP association study of the 17q21 chromosomal region linked to autism identifies CACNA1G as a novel candidate gene. Mol Psychiatry. 2009 May 19. [Epub ahead of print]

How Men And Women Cope Differently With Stress Traced To Genetic Differences By Hebrew University Researchers

SOURCE: Medical News Today

DATE: April 7, 2009 

EXCERPT: "Can people's differing reactions to situations of stress be attributed at least in part to genetic differences and do those differences affect men and women in different ways - with the edge seemingly favoring the women? Research .... would seem to indicate that the answer to both questions is yes."   more

RELATED PUBMED LINK:

Levin R, Heresco-Levy U, Bachner-Melman R, Israel S, Shalev I, Ebstein RP. Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition. Psychoneuroendocrinology. 2009 Feb 3. [Epub ahead of print] 

Men Are The Weaker Sex

SOURCE:  Medical News Today

DATE:  April 2, 2009

EXCERPT: "In a study presented to the Israel Society for Gender Based Medicine, researchers concluded that male fetuses come with "a higher association of risks,  ....   in general, boys are more vulnerable in their life in utero, and this vulnerability continues to exist throughout their lives .... "    more

RELATED PUBMED LINK:

Glezerman M. Discrimination by good intention: gender-based medicine. Isr Med Assoc J. 2009 Jan;11(1):39-41. No abstract available.  Free full text

Women More Vulnerable To Cigarette Harm

SOURCE: Medical News Today

DATE:  March 9, 2009

EXCERPT: "Studies of twins have revealed significant genetic differences between men and women who smoke who develop lung disease. According to Swedish researchers, women are more susceptible to the consequences of smoking than men."   more

RELATED LINK:

Svartengren M, et al. Twin Studies of interaction between smoking and genetic factors in the development of chronic bronchitis [Abstract]. The genetics of lung disease [panel]. Biochemical Society Focused Meeting. Loughborough, UK.(5 March, 2009) [Proceedings to be published in Biochemical Society Transactions].

Women's chromosome division different from men's

SOURCE: Science News online

DATE: November 12, 2008

EXCERPT: "Women and men sometimes do things differently, right down to divvying up their genetic legacies. 

This divvying up is known as meiosis, a process that cuts the number of chromosomes in half during the production of eggs and sperm. Men do meiosis by the textbook, but women play it looser with the process ...  in addition, women’s chromosomes don’t behave the way men’s do."    more

RELATED:

Reported by Terry Hassold, geneticist, Washington State University-Pullman on Nov. 12 at the annual meeting of the American Society of Human Genetics, Philadelphia.

Importance Of Sex-specific Testing Shown In Anxiety Study

SOURCE: Medical News Today

DATE:  October 15, 2008

EXCERPT:  "Like their human counterparts, male and female mice are not only different, their respective genetic responses can often be the reverse of what you'd expect from pharmacological results. This has important ramifications for laboratory and clinical testing. ....  The outcomes tell us that you have to do both genetic studies and pharmacological studies to get the whole picture and see what your gene of interest is really doing."  more

RELATED PUBMED LINK:

Karl T, Duffy L, Herzog H. Abstract. Behavioural profile of a new mouse model for NPY deficiency. Eur J Neurosci. 2008 Jul;28(1):173-80.

Genes could explain memory differences between men and women

SOURCE: Telegraph.co.uk

DATE:  July 20, 2008

EXCERPT:  "Researchers at the Institute of Psychiatry, King's College London, have found that males use different genes from females when making the new connections in the brain that are needed to create long-term memories. They believe this might explain why men are far better at remembering "tactical" memories, such as travel directions and trivia, while women form more "emotional" memories such as birthdays, wedding anniversaries and details about the world around them."   more

Male And Female Brains Have Evolutionarily Conserved Sexual Signatures

SOURCE:  Medical News Today

DATE:  June 21, 2008

EXCERPT:  "An article published in the open-access journal PLoS Genetics reports that male and female primates and humans have hundreds of biological differences that are evident in gene expressions in the cerebral cortex.  ....  They believe that the insights provided by this study may help explain some of the psychiatric diseases with differences in males and females  ....  [and] may be used in the future to calculate medical dosages, as well as for other treatments of diseases or damage to the brain."   more

RELATED PUBMED LINK:

Reinius B, Saetre P, Leonard JA, Blekhman R, Merino-Martinez R, Gilad Y, Jazin E. An evolutionarily conserved sexual signature in the primate brain. PLoS Genet. 2008 Jun 20;4(6):e1000100.     Free full text article in PMC.

Gene Variants Indicate Opposite Survival Outcomes For Women And Men With Colon Cancer

SOURCE: Medical News Today

DATE: April 16, 2008

EXCERPT: "A new study ... found that specific gene variants linked to the development of colon cancer resulted in opposite survival outcomes for men and women."  more

RELATED PUBMED LINK

Press OA, Zhang W, Gordon MA, Yang D, Lurje G, Iqbal S, El-Khoueiry A, Lenz HJ. Gender-related survival differences associated with EGFR polymorphisms in metastatic colon cancer. Cancer Res. 2008 Apr 15;68(8):3037-42.