GenderBiology.net

Gene Linked To Lupus Might Explain Gender Difference In Disease Risk

SOURCE: Medical News Today

DATE:  March 31, 2009

EXCERPT: "In an international human genetic study, researchers at UT Southwestern Medical Center have identified a gene linked to the autoimmune disease lupus, and its location on the X chromosome might help explain why females are 10 times more susceptible to the disease than males."   more

RELATED PUBMED LINK:

Jacob CO, Zhu J, Armstrong DL, Yan M, Han J, Zhou XJ, Thomas JA, Reiff A, Myones BL, Ojwang JO, Kaufman KM, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Silverman E, Ziegler J, Kelly JA, Merrill JT, Harley JB, Ramsey-Goldman R, Vila LM, Bae SC, Vyse TJ, Gilkeson GS, Gaffney PM, Moser KL, Langefeld CD, Zidovetzki R, Mohan C. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2009 Mar 27. [Epub ahead of print]

 

Hormone Cream Smoothes Skin Not Damaged by Sun CME (with audio)

SOURCE: MedPage Today

DATE:  September 15, 2008

EXCERPT: "Estradiol cream stimulated collagen production which smoothed wrinkled skin in elderly women, but only in areas that had not been exposed to the sun, researchers here reported. ...  And the effect of estradiol appeared to be gender-specific. For example, although men did have a benefit, it was less than the response observed in women."    more

RELATED PUBMED LINK:

Rittié L, Kang S, Voorhees JJ, Fisher GJ. Abstract. Induction of collagen by estradiol: difference between sun-protected and photodamaged human skin in vivo. Arch Dermatol. 2008 Sep;144(9):1129-40.

FDA Warns of Injection-Site Reactions with Naltrexone for Alcoholism

SOURCE: MedPageTODAY

DATE:  August 14, 2008

EXCERPT: "  Serious injection-site reactions, including abscesses that required surgical treatment up to debridement, have been reported in patients given naltrexone (Vivitrol) injections for alcoholism prevention.   ...  The FDA said data indicated that there is a variable depth of subcutaneous tissue dependent on the gender and weight of the patient. "Women may be physiologically at higher risk for injection-site reactions due to typically higher gluteal fat thickness," the FDA said. ..."   more

RELATED LINK:

FDA ALERT [08/12/2008]  Information for Healthcare Professionals:  Naltrexone Injection Site Reactions
[naltrexone for extended-release injectable suspension (marketed as Vivitrol)] http://www.fda.gov/cder/drug/InfoSheets/HCP/naltrexoneHCP.htm

Scientists Identify Genes Linked To Lupus In Women

SOURCE:  Medical News Today

DATE:  January 22, 2008

EXCERPT:  "An international consortium of scientists has identified multiple genes that are linked to systemic lupus erythematosus, a devastating autoimmune disease that affects between 1 million and 2 million Americans.  .....  Systemic lupus can involve the joints, kidneys, heart, lungs, brain and blood. The disease .... affects women nine times more frequently than men."     more

RELATED PUBMED LINK:

Nath SK, Han S, Kim-Howard X, Kelly JA, Viswanathan P, Gilkeson GS, Chen W, Zhu C, McEver RP, Kimberly RP, Alarcón-Riquelme ME, Vyse TJ, Li QZ, Wakeland EK, Merrill JT, James JA, Kaufman KM, Guthridge JM, Harley JB. A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet. 2008 Feb;40(2):152-4. Epub 2008 Jan 20.

A different side of estrogen

SOURCE:  Science News

DATE:  January 5, 2008

EXCERPT:   ""Estrogen receptor beta, in particular, is involved in many, many tissues. It shows that estrogens are extremely important not only in reproduction, which everybody knows, but in other aspects of health as well," says Gustafsson, of the Karolinska Institute in Stockholm, Sweden.  ... including pain, depression, anxiety disorders, all most every major organ system."   more

RELATED  LINK:

Williams, Sarah C. A different side of estrogen. Sci News. 2008 Jan 5;173(1):8-9.

Antioxidant Supplements May Raise Women's Skin Cancer Risk

SOURCE:  MedicineNet.com (HealthDay)

DATE:  August 20, 2007

EXCERPT:  "Taking antioxidant supplements won't protect against skin cancer and may actually boost the risk, at least in women, according to a new French study."  more

RELATED PUBMED LINK:

Hercberg S, Ezzedine K, Guinot C, Preziosi P, Galan P, Bertrais S, Estaquio C, Briancon S, Favier A, Latreille J, Malvy D. Antioxidant Supplementation Increases the Risk of Skin Cancers in Women but Not in Men. J Nutr. 2007 Sep;137(9):2098-2105.

Gender Linked To Development Of Skin Cancer

SOURCE: Medical News Today

DATE:  April 2, 2007

EXCERPT: "Inherent gender differences instead of more sun exposure may be one reason why men are three times more likely than women to develop certain kinds of skin cancer, say researchers at Ohio State University Medical Center." more 

RELATED PUBMED LINK:

Thomas-Ahner JM, Wulff BC, Tober KL, Kusewitt DF, Riggenbach JA, Oberyszyn TM. 
Gender Differences in UVB-Induced Skin Carcinogenesis, Inflammation, and DNA Damage. Cancer Res. 2007 Apr 1;67(7):3468-74. Epub 2007 Mar 27.  PMID: 17389759