Prolonged Loop Diuretic Use Modestly Boosts Fracture Risk for Women

SOURCE: MedPage Today

DATE:  January 26, 2009

EXCERPT:  "Long-term use of loop diuretics may increase fracture risk among postmenopausal women ....  Women who used loop diuretics for more than three years had a significant 16% increased risk of fractures overall and of clinical fractures other than the hip or spine ....  The findings might not be generalizable to thiazide-type diuretics -- which stimulate renal tubular calcium reabsorption and have been associated with lower fracture risk -- or to populations with lower calcium intakes, those primarily being treated with loop diuretics, or men, .... "   more

RELATED PUBMED LINK:

Carbone LD, Johnson KC, Bush AJ, Robbins J, Larson JC, Thomas A, LaCroix AZ. Loop diuretic use and fracture in postmenopausal women: findings from the Women's Health Initiative. Arch Intern Med. 2009 Jan 26;169(2):132-40.  Full text