Sex of Adult Mouse Muscle Stem Cells Affects Their Muscle Regeneration Efficiency

SOURCE:  National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) -- News & Events

DATE:  December 11, 2007

EXCERPT:   "Researchers have recently discovered that the sex of cells in a subpopulation of muscle-generating stem cells in adult mice can considerably influence their capacity to repair tissue. The finding may persuade researchers to consider the implication of relying on only male cells or female cells in research, and to report the sex of the stem cells used when publishing their findings. Their work was partly supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)."      more

RELATED PUBMED LINK:

Deasy BM, Lu A, Tebbets JC, Feduska JM, Schugar RC, Pollett JB, Sun B, Urish KL, Gharaibeh BM, Cao B, Rubin RT, Huard J. A role for cell sex in stem cell-mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency. J Cell Biol. 2007 Apr 9;177(1):73-86.

Deasy BM, Corsi KA, Huard J. [Cellular therapy can be affected by the sex of the stem cell used] Med Sci (Paris). 2007 Oct;23(10):798-800. French.